对接受长效醋酸甲羟孕酮避孕的青春期少女补充雌激素的双盲随机试验

The purpose of this clinical trial was to evaluate the effect of estrogen supplementation on bone mineral density in adolescent girls who received depot medroxyprogesterone acetate for contraception. One hundred twenty- three adolescents who began receiving depot medroxyprogesterone acetate injections every 12 weeks were assigned randomly to receive monthly injections of estradiol cypionate or placebo. The main outcome was bone mineral density that was measured by dual energy x- ray absorptiometry for 12 (n = 69) to 24 (n = 36) months. Participants, technicians, and physicians were blinded to estrogen treatment. Over the 24- month period, the percentage of change from baseline bone mineral density at the lumbar spine was 2.8% in the estrad... 下载全文