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本书的出版能够对全球的肿瘤治疗提供来自中国医药学界的有效经验和方法,并为从事医药工作的各国人士提供有科学性、实用性的最新文献资料,进一步提升医药期刊的国际影响力。

作品简介:

本书属于《中国医药进展》系列丛书,由中国知网联合期刊编辑部组织专家遴选出107篇使用西医方法治疗肿瘤的研究论文。所收录的论文均由其一次发表的期刊编委会推荐,论文内容从药物研究,以呼吸系肿瘤、泌尿生殖器肿瘤、皮肤肿瘤、神经系肿瘤、消化系肿瘤、造血器及淋巴系肿瘤等为对象的治疗机理及临床研究,以及护理研究等板块,充分展示了中国肿瘤治疗领域的前沿进展,有科学的方法学支持和客观结论。原始论文以中文发表,本书以英文译文进行精选汇编。

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Foreword by Editor-in-Chief 序言

Tumor has long been a global challenge. In the past over 200 years, treatment methods for tumor have been emerging, such as surgery, radiotherapy, chemotherapy, and targeted therapy, bringing hopes to tumor patients while inducing metastasis and drug resistance. Consumption by cachexia and various complications make tumor insuperable. Current available tumor treatment methods in western medicine are surgery, radiotherapy, biotherapy (including hormone therapy, cell immunotherapy, targeted therapy, and vaccine therapy), gene therapy, and chemotherapy, and more methods are being constantly innovated. Targeted therapy and photodynamic therapy have been applied in clinical practice. Despite the rapid advancement of modern technology and medical care, the antitumor mechanisms of many drugs remain unclear and new drugs are yet to be explored. In recent years, researchers in China have actively developed antitumor drugs, optimized the chemical structures of related drugs, elucidated antitumor mechanisms of them, and improved the nursing of tumor patients, making great contributions to the treatment and recovery of tumor patients.

Since 2014, Acta Pharmaceutica Sinica, The Chinese Journal of Clinical Pharmacology, Chinese Journal of Medicinal Chemistry, Chinese Journal of Clinical Oncology, Chinese Pharmacological Bulletin, Chinese Pharmaceutical Journal, Chinese Journal of Nursing, and Chinese Journal of Biotechnology have been selected for Journal Translation Project (JTP, http://jtp.cnki.net/bilingual). As of 2020, 1 908 articles from these journals have been included in the platform and published in Chinese and English, which has enhanced the international influence of these journals. To further promote the international dissemination of these journals and to inform more readers about the latest progress in tumor treatment with western medicine in China, China National Knowledge Infrastructure collaborated with the editorial offices of these journals to constitute a panel of experts and select 107 excellent articles on tumor treatment with western medicine. The English versions of these articles were compiled into the book Tumor (Western Medicine) as part of China’s Medicine Progress Series. These articles were recommended by the editorial boards of the journals in which they were originally published in Chinese, covering comprehensive drug research, hematopoietic organ and lymphoid tumors, respiratory system tumor, nursing research, urogenital tumor, skin tumor, neurological tumor, and digestive system tumor. These articles fully demonstrate the cutting-edge advances in tumor treatment in China, with scientific methodological support and objective conclusions. The original articles were published in Chinese, and this book is a compilation of English version of selected articles.

As the editor-in-chief, I believe this book will provide experience and methods from the Chinese medicinal community for tumor treatment worldwide. This is of scientific value and practical significance for global medical professionals.

Editor-in-chief: CHENG Maosheng

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Part 1 Comprehensive Drug Research
Optimized Expression, Preparation of Human Papillomavirus 1...
Site-directed Mutagenesis of Human IL-29 and Antineoplastic...
Expression, Purification of Recombinant Cationic Peptide AI...
Apoptosis Induced by Transferring Cytosine Deaminase Suicid...
Synthesis and Antiproliferative Evaluation of Steroidal Com...
Anti-tumor Effects and Mechanisms of the Fully Human Anti-E...
Synthesis, Antitumor Activity and Molecular Docking of Quin...
Synthesis and Pharmacological Evaluation of Novel Cycloprop...
Design, Synthesis and Antiproliferative Activity Evaluation...
Synthesis of Binuclear Copper(II) Complex with Salicylaldeh...
Screening of Small Molecule Inhibitors for PLK1 PBD and Eva...
Anti-tumor Activity of HER-specific Peptide Vaccines-CKL9 a...
In Vitro Metabolism and Drug-drug Interaction Potential of ...
Preliminary Study of Lipid Bilayer-coated Calcium Phosphate...
Design, Synthesis and Antitumor Activities of Cyclopropane ...
Synthesis and Antitumor Activity of Novel ALK and c-Met Kin...
Alkaloids from the Marine-derived Fungus Aspergillus fumiga...
Improved Synthesis of ALK Inhibitor Brigatinib
Synthesis and Antitumor Activity Evaluation of Imidazol-2-p...
Preparation and Evaluation of Anti-tumor Metastasis of Self...
Design, Synthesis and Pharmacological Activities of 1,4-die...
Construction of HER2-specific CAR-T Cells and In Vitro Anal...
Synthesis and Antitumor Activity of 4'-Demethylepipodophyll...
Isolation, Purification and Antitumor Activity of Bacillomy...
Preparation and Properties of Heparosan Polysaccharide-vita...
Impacts of Particle Shape on Cellular Uptake and Tumor Imag...
An Efficient Synthesis of Antitumor Drug Cabazitaxel
Preparation of Thermoresponsive Micelles Loaded with Indocy...
Synthesis and Antitumor Activity of δ-Lactam Compounds
Synthesis and Antitumor Activity Evaluation of Quinoline De...
Design, Synthesis and Study of Anti-tumor Activity of Thiaz...
Synthesis and Antitumor Activity of Arylaminopyrimidines Be...
Design, Synthesis and Antitumor Activity Evaluation of Nove...
Design, Synthesis and Biological Activity of Twin Drugs of ...
Synthesis and Antitumor Activity of Fluoroquinolone C-3 Ary...
Synthesis and Antitumor Activity In Vitro of Novel PARP-1 I...
Design, Synthesis and Biological Evaluation of Benzenesulfo...
Construction and Anti-tumor Efficacy of a Peptide Vaccine t...
Effect of Gap Junctions on Anti-proliferation Effect of miR...
Design, Synthesis and Biological Evaluation of Diphenyl-bas...
Part 2 Mechanism Study
Construction of an Enediyne-energized Fusion Protein LDP-IG...
Synergistic Anti-tumor Effects of Axitinib and Doxorubicin
Effect of Cx43 on Acquired Gefitinib-resistance Mechanisms ...
Proliferative Mechanism of Microrna-543 on Non-Small Cell L...
In Vitro Targeting Efficiency Evaluation of Reduction-respo...
Liposomal Melatonin Dry Powder Inhalers for the Treatment o...
Tumor Targeting and Suppression Effect in Nude Mice Induced...
Construction and Anti-tumor Efficacy of a Pentameric Peptid...
A System Review: Comparison of Doxorubicin and Epirubicin C...
Reversal of Breast Cancer Multidrug Resistance In Vitro by ...
Antitumor Effect of Supernatant from Co-culture of Human Em...
Endogenous Oxindole Isatin Induces Apoptosis of MCF-7 Breas...
Olaparib Potentiates the Antitumor Effect of Taxol on 4T1 B...
Important Role of ELMO1 in Invasion and Migration of Breast...
Mechanism Research of Apatinib-treated Breast Cancer Based ...
Treatment of Triple Negative Breast Cancer Cells with Combi...
Study of Cisplatin Aggravating DNA Damage and Causing a Hig...
Establishment of Breast Cancer Cells with Stable Expression...
Relationship between CMPK1 Protein and ADM Caused Multidrug...
Matrix Stiffness Regulates Cell Uptake of Nanoparticles in ...
Co-culture of Human Breast Adenocarcinoma Cells and Human U...
A UPLC-MS/MS Method for Quantification of a Novel Doxorubic...
In Vitro Anticancer Effect of Combretastatin A4 Liposomes i...
Reversal Effect and Mechanism of 15-PGHD Induction Drugs on...
Reverse Effect of miR-186-5p on Adriamycin Resistance of Br...
Mechanisms of Doxorubicin Resistance of Breast Cancer MCF-7...
Inhibition of Proliferation of Breast Cancer Cells by Down-...
Norepinephrine Increases Risk of Breast Cancer in Depressed...
Anti-tumor Effect and Impact on Tumor Immune Microenvironme...
Apoptosis-inducing Effect of 5-Fluorouracil Combined with R...
Mechanism of IL-1β Enhancing Blood-brain Tumor Barrier Per...
Identification of In Vivo Activity of Defactinib-microcryst...
Expression and Clinical Significance of CXCL14 and EGFR in ...
Single Nucleotide Polymorphisms Analysis of Drug Related Ge...
Label-free Quantitative Proteomic Analysis of Acquired Herc...
Preliminary Study of Peptide from Periplaneta americana on ...
Part 3 Clinical Study
Effect of Family History of Cancer on Clinical Features and...
Relationship between MAPK1 Gene Polymorphism and Gefitinib ...
Comparative Analysis of Immediate Breast Reconstruction aft...
Adverse Reactions of Chemoradiotherapy with Docetaxel after...
Clinical Value of Combining Indocyanine Green Fluorescence ...
Diagnosis Value of Ultrasound-guided Core-needle Biopsy in ...
Effectiveness of Computer-based Monitoring System for Patie...
A Cost-effectiveness Analysis of Adjuvant Trastuzumab Regim...
Effect of Everolimus on the Treatment of 1 Case of Refracto...
Design and Clinical Application of Rehabilitation VR System...
Development of Continuing Nursing Evaluation System for Pat...
Consistency Study of Self-reports and Nursing Notes in Adju...
Application and Effect of Virtual Cognitive Rehabilitation ...
A Trajectory Study of Sleep and Related Symptoms in Breast ...
Ultrasound-guided Percutaneous Nephrostomy for the Treatmen...
Perioperative Nursing of Three Patients Undergoing Resectio...
Establishment and Application of Respiratory Function Train...
Microsurgical Treatment of Spinal Cord Congenital Tumors
Changes of Circulating Tumor Cells in Locally Advanced Esop...
A Comparative Analysis of the Incidence Rates of Esophageal...
Analysis of Short- and Long-term Outcomes after Esophagecto...
Efficacy of S-1 Combined with Cisplatin as First-line Chemo...
Association of Serum PGE-2 and VEGF Levels and the Expressi...
Correlation between Preoperative NLR, PLR, and RDW and Clin...
Association of Preoperative Platelet Distribution Width wit...
Analysis of Clinical Adverse Reactions of Apatinib for the ...
Analysis of Clinical Characteristics and Prognosis of 63 Ca...
Clinical Analysis of Rituximab-induced Interstitial Pneumon...
Part 4 Nursing Research
Effects of Different Gargling Methods of Sodium Bicarbonate...
Clinical Application of Located Subcutaneous Jugular Vein I...
A Qualitative Research on Role Cognition and Experience amo...
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